Evaluation of the metabolism of PEP06, an endostatin-RGDRGD 30-amino-acid polypeptide and a promising novel drug for targeting tumor cells

PEP06 is a novel endostatin-Arg-Gly-Asp-Arg-Gly-Asp (RGDRGD) 30-amino-acid polypeptide featuring a terminally fused RGDRGD hexapeptide at the N terminus. The active endostatin fragment of PEP06 directly targets tumor cells and exerts an antitumoral effect. However, little is known about the kinetics...

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Auteurs principaux:	Liyun Niu, Huiyu Zhou, Yueru Lian, Ya Gao, Yulu Liu, Ruolan Gu, Zhuona Wu, Xiaoxia Zhu, Hui Gan, Zhiyun Meng, Guifang Dou
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2022-10-01
Collection:	Journal of Pharmaceutical Analysis
Sujets:	PEP06 HRMS Metabolic stability Metabolites identification
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S209517792200020X
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