Evaluation of the metabolism of PEP06, an endostatin-RGDRGD 30-amino-acid polypeptide and a promising novel drug for targeting tumor cells

PEP06 is a novel endostatin-Arg-Gly-Asp-Arg-Gly-Asp (RGDRGD) 30-amino-acid polypeptide featuring a terminally fused RGDRGD hexapeptide at the N terminus. The active endostatin fragment of PEP06 directly targets tumor cells and exerts an antitumoral effect. However, little is known about the kinetics...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Liyun Niu, Huiyu Zhou, Yueru Lian, Ya Gao, Yulu Liu, Ruolan Gu, Zhuona Wu, Xiaoxia Zhu, Hui Gan, Zhiyun Meng, Guifang Dou
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Elsevier 2022-10-01
Sarja:	Journal of Pharmaceutical Analysis
Aiheet:	PEP06 HRMS Metabolic stability Metabolites identification
Linkit:	http://www.sciencedirect.com/science/article/pii/S209517792200020X
Tagit:	Lisää tagi Ei tageja, Lisää ensimmäinen tagi!