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Phosphatase activity of the control of virulence sensor kinase CovS is critical for the pathogenesis of group A streptococcus.

The control of virulence regulator/sensor kinase (CovRS) two-component system is critical to the infectivity of group A streptococcus (GAS), and CovRS inactivating mutations are frequently observed in GAS strains causing severe human infections. CovS modulates the phosphorylation status and with it...

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Principais autores: Nicola Horstmann, Chau Nguyen Tran, Chelcy Brumlow, Sruti DebRoy, Hui Yao, Graciela Nogueras Gonzalez, Nishanth Makthal, Muthiah Kumaraswami, Samuel A Shelburne
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2018-10-01
Serier:PLoS Pathogens
Online adgang:https://doi.org/10.1371/journal.ppat.1007354
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