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A Critical Role of Zinc Importer AdcABC in Group A Streptococcus-Host Interactions During Infection and Its Implications for Vaccine Development

Bacterial pathogens must overcome host immune mechanisms to acquire micronutrients for successful replication and infection. Streptococcus pyogenes, also known as group A streptococcus (GAS), is a human pathogen that causes a variety of clinical manifestations, and disease prevention is hampered by...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Nishanth Makthal, Kimberly Nguyen, Hackwon Do, Maire Gavagan, Pete Chandrangsu, John D. Helmann, Randall J. Olsen, Muthiah Kumaraswami
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017-07-01
Schriftenreihe:EBioMedicine
Schlagworte:
Group A streptococcus
Host-pathogen interactions
Nutritional immunity
Gene regulation
GAS vaccine
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2352396417302281
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