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Determination of 6258-70, a new semi-synthetic taxane, in rat plasma and tissues: Application to the pharmacokinetics and tissue distribution study

Cancer is the leading cause of death all over the world. Among the chemotherapy drugs, taxanes play an important role in cancer treatment. 6258-70 is a new semi-synthetic taxane which has a broad spectrum of antitumor activity. A fast and reliable high performance liquid chromatography-tandem mass s...

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Principais autores: Simin Zhao, Yuanyuan Zhang, Ping Ju, Liqiang Gu, Rui Zhuang, Longshan Zhao, Xing Tang, Kaishun Bi, Xiaohui Chen
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2016-08-01
Series:Journal of Pharmaceutical Analysis
Assuntos:
6258-70
HPLC–MS/MS
Pharmacokinetics
Tissue distribution
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2095177916300077
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