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Enhanced Lymphatic Delivery of Methotrexate Using W/O/W Nanoemulsion: In Vitro Characterization and Pharmacokinetic Study

Methotrexate, which is widely used in the treatment of cancer and immune-related diseases, has limitations in use because of its low bioavailability, short half-life, and tissue toxicity. Thus, in this study, a nano-sized water-in-oil-in-water (W/O/W) double emulsion containing methotrexate was prep...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Hauptverfasser: Ji-Hun Jang, Seung-Hyun Jeong, Yong-Bok Lee
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2020-10-01
Schriftenreihe:Pharmaceutics
Schlagworte:
Online-Zugang:https://www.mdpi.com/1999-4923/12/10/978
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