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Induction of Oxidative Stress and Ferroptosis in Triple-Negative Breast Cancer Cells by Niclosamide via Blockade of the Function and Expression of SLC38A5 and SLC7A11

The amino acid transporters SLC38A5 and SLC7A11 are upregulated in triple-negative breast cancer (TNBC). SLC38A5 transports glutamine, methionine, glycine and serine, and therefore activates mTOR signaling and induces epigenetic modifications. SLC7A11 transports cystine and increases the cellular le...

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Main Authors: Marilyn Mathew, Sathish Sivaprakasam, Gunadharini Dharmalingam-Nandagopal, Souad R. Sennoune, Nhi T. Nguyen, Valeria Jaramillo-Martinez, Yangzom D. Bhutia, Vadivel Ganapathy
Format: Artigo
Language:Inglês
Published: MDPI AG 2024-02-01
Series:Antioxidants
Subjects:
SLC38A5
SLC7A11
TNBC cells
seleno-methionine
glutathione
glutathione peroxidase
Online Access:https://www.mdpi.com/2076-3921/13/3/291
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