Induction of Oxidative Stress and Ferroptosis in Triple-Negative Breast Cancer Cells by Niclosamide via Blockade of the Function and Expression of SLC38A5 and SLC7A11

The amino acid transporters SLC38A5 and SLC7A11 are upregulated in triple-negative breast cancer (TNBC). SLC38A5 transports glutamine, methionine, glycine and serine, and therefore activates mTOR signaling and induces epigenetic modifications. SLC7A11 transports cystine and increases the cellular le...

Disgrifiad llawn

Manylion Llyfryddiaeth

Prif Awduron:	Marilyn Mathew, Sathish Sivaprakasam, Gunadharini Dharmalingam-Nandagopal, Souad R. Sennoune, Nhi T. Nguyen, Valeria Jaramillo-Martinez, Yangzom D. Bhutia, Vadivel Ganapathy
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	MDPI AG 2024-02-01
Cyfres:	Antioxidants
Pynciau:	SLC38A5 SLC7A11 TNBC cells seleno-methionine glutathione glutathione peroxidase
Mynediad Ar-lein:	https://www.mdpi.com/2076-3921/13/3/291
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!