Neuronal Sprouting and Reorganization in Bone Tissue Infiltrated by Human Breast Cancer Cells

BackgroundPain is a common complication for patients with metastatic bone disease. Animal models suggest that the pain, in part, is driven by pathological sprouting and reorganization of the nerve fibers innervating the bone. Here, we investigate how these findings translate to humans.MethodsBone bi...

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Hlavní autoři:	Rie B. Hansen, Manasi Sayilekshmy, Michala S. Sørensen, Astrid H. Jørgensen, Ida B. Kanneworff, Emma K. E. Bengtsson, Tomas A. Grum-Schwensen, Michael M. Petersen, Charlotte Ejersted, Thomas L. Andersen, Christina M. Andreasen, Anne-Marie Heegaard
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-05-01
Edice:	Frontiers in Pain Research
Témata:	cancer-induced bone pain metastatic bone disease neuronal sprouting bone innervation breast cancer
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fpain.2022.887747/full
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