Deficiency of glucocorticoid receptor in bone marrow adipocytes has mild effects on bone and hematopoiesis but does not influence expansion of marrow adiposity with caloric restriction

IntroductionUnlike white adipose tissue depots, bone marrow adipose tissue (BMAT) expands during caloric restriction (CR). Although mechanisms for BMAT expansion remain unclear, prior research suggested an intermediary role for increased circulating glucocorticoids. MethodsIn this study, we utilized...

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Principais autores:	Rebecca L. Schill, Jack Visser, Mariah L. Ashby, Ziru Li, Kenneth T. Lewis, Antonio Morales-Hernandez, Keegan S. Hoose, Jessica N. Maung, Romina M. Uranga, Hadla Hariri, Isabel D. K. Hermsmeyer, Hiroyuki Mori, Ormond A. MacDougald
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2024-06-01
Series:	Frontiers in Endocrinology
Assuntos:	glucocorticoids (GC) glucocorticoid receptor (GR) bone marrow adipose tissue (BMAT) caloric restriction (CR) bone hematopoiesis
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fendo.2024.1397081/full
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