Targeting the ODC1-YBX1 axis reverses gastric cancer chemoresistance via transcriptional control of SLC7A11-mediated ferroptosis

Abstract Gastric adenocarcinoma (STAD), a leading cause of cancer mortality, faces major therapeutic challenges due to intrinsic and acquired chemoresistance. Chemoresistance is intricately linked to ferroptosis.Elucidating the mechanisms of chemotherapy resistance in STAD represents a critical unme...

Whakaahuatanga katoa

Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Ruiqi Li, Shantanu Baral, Fanyu Zhao, Chenkai Zhang, Jiajie Zhou, Ben Li, Yifan Cheng, Dengyang Fang, Zijie Xu, Yayan Fu, Jianyue Ding, Zhen Tian, Shuai Zhao, Jie Wang, Mengli Zi, Longhe Sun, Xuetong Jiang, Qiannan Sun, Daorong Wang
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Publishing Group 2026-04-01
Rangatū:	Cell Death Discovery
Urunga tuihono:	https://doi.org/10.1038/s41420-026-03067-1
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!