Targeting the ODC1-YBX1 axis reverses gastric cancer chemoresistance via transcriptional control of SLC7A11-mediated ferroptosis

Abstract Gastric adenocarcinoma (STAD), a leading cause of cancer mortality, faces major therapeutic challenges due to intrinsic and acquired chemoresistance. Chemoresistance is intricately linked to ferroptosis.Elucidating the mechanisms of chemotherapy resistance in STAD represents a critical unme...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Ruiqi Li, Shantanu Baral, Fanyu Zhao, Chenkai Zhang, Jiajie Zhou, Ben Li, Yifan Cheng, Dengyang Fang, Zijie Xu, Yayan Fu, Jianyue Ding, Zhen Tian, Shuai Zhao, Jie Wang, Mengli Zi, Longhe Sun, Xuetong Jiang, Qiannan Sun, Daorong Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2026-04-01
Colecção:	Cell Death Discovery
Acesso em linha:	https://doi.org/10.1038/s41420-026-03067-1
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!