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Harnessing Gut Endocrine Cell Plasticity to Restore Insulin Production

Type 1 diabetes (T1D) results from autoimmune-mediated destruction of pancreatic β-cells, leading to insulin deficiency and chronic hyperglycemia. β-cell replacement represents a promising therapeutic strategy, yet the identification of a sustainable and immune-compatible cell source remains a major...

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Hoofdauteurs: Chaïma Ayachi, Tiziana Napolitano, Serena Silvano, Sophie Giorgetti-Peraldi, Ahmed Mansouri, Raphaël Rapetti-Mauss, Hugo Fofo, Valentin Lepage, Laura Etasse, Caroline Treins, Loan Tran, Patrick Collombat
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2026-03-01
Reeks:Cells
Onderwerpen:
gastrointestinal tract
L-cells
cellular reprogramming
<i>Pax4</i>
β-cell regeneration
type 1 diabetes
Online toegang:https://www.mdpi.com/2073-4409/15/6/544
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