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MKRN3 Interacts With Several Proteins Implicated in Puberty Timing but Does Not Influence GNRH1 Expression

Paternally-inherited loss-of-function mutations in makorin ring finger protein 3 gene (MKRN3) underlie central precocious puberty. To investigate the puberty-related mechanism(s) of MKRN3 in humans, we generated two distinct bi-allelic MKRN3 knock-out human pluripotent stem cell lines, Del 1 and Del...

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Principais autores: Venkatram Yellapragada, Xiaonan Liu, Carina Lund, Johanna Känsäkoski, Kristiina Pulli, Sanna Vuoristo, Karolina Lundin, Timo Tuuri, Markku Varjosalo, Taneli Raivio
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019-02-01
Serier:Frontiers in Endocrinology
Fag:
MKRN3
puberty timing
protein interaction
GNRH1
CRISPR/Cas9
Online adgang:https://www.frontiersin.org/article/10.3389/fendo.2019.00048/full
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