Heterozygous FBXO7 as potential genetic modifiers in early-onset Parkinson’s disease with levodopa responsive non-motor features

Objective: To report a retrospective clinical series of four patients diagnosed with early-onset Parkinson’s disease (EOPD) carrying heterozygous variants of uncertain significance (VUSs) in the FBXO7 gene. Background: FBXO7 encodes an F-box-domain-containing protein involved in the mitophagy proces...

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Ngā kaituhi matua:	Lorenzo Malfer, Andrea Giorgi, Tina Liu, Capucine Piat, Ali Zare Dehnavi, Owen A. Ross, Zhiyv Niu, Eduardo E. Benarroch, James H. Bower, Rodolfo Savica
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Elsevier 2026-03-01
Rangatū:	Brain Disorders
Ngā marau:	Early-onset Parkinson’s disease PARK15 FBXO7 Autonomic symptoms
Urunga tuihono:	http://www.sciencedirect.com/science/article/pii/S2666459325001234
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!