Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defects

Abstract Tauopathies are a group of neurodegenerative diseases characterized by the presence of tau inclusions. We have developed over fifty anti-tau single-domain antibodies (sdAbs) derived from phage display libraries of a llama immunized with recombinant and pathological tau immunogens. We examin...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Sudershana Nair, Yixiang Jiang, Isabella S. Marchal, Elizabeth Chernobelsky, Huai-Wei Huang, Sarah Suh, Ruimin Pan, Xiang-Peng Kong, Hyung Don Ryoo, Einar M. Sigurdsson
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2024-07-01
Schriftenreihe:	Cell Death and Disease
Online-Zugang:	https://doi.org/10.1038/s41419-024-06927-9
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