Pro-Inflammatory Signaling Upregulates a Neurotoxic Conotoxin-Like Protein Encrypted Within Human Endogenous Retrovirus-K

Motor neuron degeneration and spinal cord demyelination are hallmark pathological events in Amyotrophic Lateral Sclerosis (ALS). Endogenous retrovirus-K (ERVK) expression has an established association with ALS neuropathology, with murine modeling pointing to a role for the ERVK envelope (<i>env</i>...

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Autori principali:	Domenico Di Curzio, Mamneet Gurm, Matthew Turnbull, Marie-Josée Nadeau, Breanna Meek, Julia D. Rempel, Samuel Fineblit, Michael Jonasson, Sherry Hebert, Jennifer Ferguson-Parry, Renée N. Douville
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2020-06-01
Serie:	Cells
Soggetti:	endogenous retrovirus amyotrophic lateral sclerosis conotoxin HIV Tat NF-κB necroptosis
Accesso online:	https://www.mdpi.com/2073-4409/9/7/1584
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