Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.

Mammalian Target of Rapamycin Complex 1 (mTORC1) is activated by growth factor-regulated phosphoinositide 3-kinase (PI3K)/Akt/Rheb signalling and extracellular amino acids (AAs) to promote growth and proliferation. These AAs induce translocation of mTOR to late endosomes and lysosomes (LELs), subseq...

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Bibliographic Details

Main Authors:	Margrét H Ögmundsdóttir, Sabine Heublein, Shubana Kazi, Bruno Reynolds, Shivanthy M Visvalingam, Michael K Shaw, Deborah C I Goberdhan
Format:	Artigo
Language:	Inglês
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	https://doi.org/10.1371/journal.pone.0036616
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