Spatial Distribution of Calcium Sparks Determines Their Ability to Induce Afterdepolarizations in Human Atrial Myocytes

Summary: Analysis of the spatio-temporal distribution of calcium sparks showed a preferential increase in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF), linked to higher ryanodine receptor (RyR2) phosphorylation at s2808 and lower calsequestrin-2 levels. M...

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Principais autores:	Carmen Tarifa, PhD, Alexander Vallmitjana, PhD, Verónica Jiménez-Sábado, PhD, Miquel Marchena, PhD, Anna Llach, PhD, Adela Herraiz-Martínez, PhD, Héctor Godoy-Marín, PhD, Carme Nolla-Colomer, PhD, Antonino Ginel, MD, Xavier Viñolas, MD, José Montiel, MD, Francisco Ciruela, PhD, Blas Echebarria, PhD, Raúl Benítez, PhD, Juan Cinca, MD, Leif Hove-Madsen, PhD
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-01-01
coleção:	JACC: Basic to Translational Science
Assuntos:	atrial fibrillation human atrial myocyte ryanodine receptor sarcoplasmic reticulum transient inward currents
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2452302X22003333
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