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Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex

Aberrant signaling through the Raf/MEK/ERK (ERK/MAPK) pathway causes pathology in a family of neurodevelopmental disorders known as 'RASopathies' and is implicated in autism pathogenesis. Here, we have determined the functions of ERK/MAPK signaling in developing neocortical excitatory neurons. Our d...

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Autores principales: Lei Xing, Rylan S Larsen, George Reed Bjorklund, Xiaoyan Li, Yaohong Wu, Benjamin D Philpot, William D Snider, Jason M Newbern
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications Ltd 2016-02-01
Colección:eLife
Materias:
kinase
excitatory neuron
corticospinal
axon
excitability
Acceso en línea:https://elifesciences.org/articles/11123
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