A Small Molecule Targeting Human MEK1/2 Enhances ERK and p38 Phosphorylation under Oxidative Stress or with Phenothiazines

Small molecules are routinely used to inhibit protein kinases, but modulators capable of enhancing kinase activity are rare. We have previously shown that the small molecule INR119, designed as an inhibitor of MEK1/2, will enhance the activity of its fission yeast homologue, Wis1, under oxidative st...

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Autors principals:	Michał Otręba, Johanna Johansson Sjölander, Morten Grøtli, Per Sunnerhagen
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2021-03-01
Col·lecció:	Life
Matèries:	MAP kinase pathways redox signalling small molecule kinase modulator phenothiazines
Accés en línia:	https://www.mdpi.com/2075-1729/11/4/297
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