A Small Molecule Targeting Human MEK1/2 Enhances ERK and p38 Phosphorylation under Oxidative Stress or with Phenothiazines

Small molecules are routinely used to inhibit protein kinases, but modulators capable of enhancing kinase activity are rare. We have previously shown that the small molecule INR119, designed as an inhibitor of MEK1/2, will enhance the activity of its fission yeast homologue, Wis1, under oxidative st...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Michał Otręba, Johanna Johansson Sjölander, Morten Grøtli, Per Sunnerhagen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-03-01
coleção:	Life
Assuntos:	MAP kinase pathways redox signalling small molecule kinase modulator phenothiazines
Acesso em linha:	https://www.mdpi.com/2075-1729/11/4/297
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!