Defining early changes in Alzheimer’s disease from RNA sequencing of brain regions differentially affected by pathology

Abstract Tau pathology in Alzheimer’s disease (AD) spreads in a predictable pattern that corresponds with disease symptoms and severity. At post-mortem there are cortical regions that range from mildly to severely affected by tau pathology and neuronal loss. A comparison of the molecular signatures...

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Главные авторы:	Boris Guennewig, Julia Lim, Lee Marshall, Andrew N. McCorkindale, Patrick J. Paasila, Ellis Patrick, Jillian J. Kril, Glenda M. Halliday, Antony A. Cooper, Greg T. Sutherland
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2021-03-01
Серии:	Scientific Reports
Online-ссылка:	https://doi.org/10.1038/s41598-021-83872-z
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