IL-1β-mediated suppression of CIITA attenuates IFN-γ-induced MHC-II expression on Fibroblasts

Abstract Background Cancer-associated fibroblasts (CAFs) are key regulators in tumor microenvironment and tumor immunity, partly through MHC-II expression that modulates T-cell differentiation. However, the upstream cytokine signals controlling MHC-II expression in fibroblasts still remain poorly de...

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Detalhes bibliográficos

Principais autores:	Lujun Chen, Hongwei Jiang, Bo Tan, Renhao Geng, Junjun Chen, Shaoxian Wu, Zhang Fang, Yanyan Lang, Hui Ma, Xiao Zheng, Jingting Jiang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-12-01
coleção:	Cell Communication and Signaling
Assuntos:	IFN-γ IL-1β Fibroblasts MHC-II CIITA
Acesso em linha:	https://doi.org/10.1186/s12964-025-02575-4
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