DNA methylation and transcriptomic features are preserved throughout disease recurrence and chemoresistance in high grade serous ovarian cancers

Abstract Background Little is known about the role of global DNA methylation in recurrence and chemoresistance of high grade serous ovarian cancer (HGSOC). Methods We performed whole genome bisulfite sequencing and transcriptome sequencing in 62 primary and recurrent tumors from 28 patients with sta...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Nicole Gull, Michelle R. Jones, Pei-Chen Peng, Simon G. Coetzee, Tiago C. Silva, Jasmine T. Plummer, Alberto Luiz P. Reyes, Brian D. Davis, Stephanie S. Chen, Kate Lawrenson, Jenny Lester, Christine Walsh, Bobbie J. Rimel, Andrew J. Li, Ilana Cass, Yonatan Berg, John-Paul B. Govindavari, Joanna K. L. Rutgers, Benjamin P. Berman, Beth Y. Karlan, Simon A. Gayther
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2022-07-01
Sarja:	Journal of Experimental & Clinical Cancer Research
Aiheet:	High grade serous ovarian cancer Methylation Chemoresistance Epigenetics Whole genome bisulfite sequencing Computational methods
Linkit:	https://doi.org/10.1186/s13046-022-02440-z
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