Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver

In the liver, energy homeostasis is mainly regulated by mechanistic target of rapamycin (mTOR) signalling, which influences relevant metabolic pathways, including lipid metabolism. However, the Hedgehog (Hh) pathway is one of the newly identified drivers of hepatic lipid metabolism. Although the lin...

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主要な著者:	Luise Spormann, Christiane Rennert, Erik Kolbe, Fritzi Ott, Carolin Lossius, Robert Lehmann, Rolf Gebhardt, Thomas Berg, Madlen Matz-Soja
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2020-07-01
シリーズ:	Cells
主題:	mTOR hedgehog liver hepatocytes cyclopamine rapamycin
オンライン･アクセス:	https://www.mdpi.com/2073-4409/9/8/1817
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