APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1

ABSTRACT HIV-1 must overcome multiple innate antiviral mechanisms to replicate in CD4+ T lymphocytes and macrophages. Previous studies have demonstrated that the apolipoprotein B mRNA editing enzyme polypeptide-like 3 (APOBEC3, A3) family of proteins (at least A3D, A3F, A3G, and stable A3H haplotype...

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Bibliografiske detaljer

Principais autores:	Terumasa Ikeda, Ryo Shimizu, Hesham Nasser, Michael A. Carpenter, Adam Z. Cheng, William L. Brown, Daniel Sauter, Reuben S. Harris
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology 2023-08-01
Serier:	mBio
Fag:	HIV-1 APOBEC3 G-to-A mutations deaminase-dependent mechanism deaminase-independent mechanism Vif
Online adgang:	https://journals.asm.org/doi/10.1128/mbio.00782-23
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