Single-cell RNA-seq analysis and cell-cluster deconvolution of the human preovulatory follicular fluid cells provide insights into the pathophysiology of ovarian hyporesponse

Reduction in responsiveness to gonadotropins or hyporesponsiveness may lead to the failure of in vitro fertilization (IVF), due to a low number of retrieved oocytes. The ovarian sensitivity index (OSI) is used to reflect the ovarian responsiveness to gonadotropin stimulation before IVF. Although int...

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Hlavní autoři:	Kristine Roos, Ilmatar Rooda, Robyn-Stefany Keif, Maria Liivrand, Olli-Pekka Smolander, Andres Salumets, Agne Velthut-Meikas
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-10-01
Edice:	Frontiers in Endocrinology
Témata:	ovarian sensitivity index IVF hyporesponse preovulatory follicle bulk RNA-seq single-cell RNA-seq
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fendo.2022.945347/full
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