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Single-cell RNA-seq analysis and cell-cluster deconvolution of the human preovulatory follicular fluid cells provide insights into the pathophysiology of ovarian hyporesponse

Reduction in responsiveness to gonadotropins or hyporesponsiveness may lead to the failure of in vitro fertilization (IVF), due to a low number of retrieved oocytes. The ovarian sensitivity index (OSI) is used to reflect the ovarian responsiveness to gonadotropin stimulation before IVF. Although int...

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Principais autores: Kristine Roos, Ilmatar Rooda, Robyn-Stefany Keif, Maria Liivrand, Olli-Pekka Smolander, Andres Salumets, Agne Velthut-Meikas
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-10-01
Serier:Frontiers in Endocrinology
Fag:
ovarian sensitivity index
IVF
hyporesponse
preovulatory follicle
bulk RNA-seq
single-cell RNA-seq
Online adgang:https://www.frontiersin.org/articles/10.3389/fendo.2022.945347/full
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