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KRASG12C inhibition using MRTX1257: a novel radio-sensitizing partner

Abstract Background KRAS activating mutations are considered the most frequent oncogenic drivers and are correlated with radio-resistance in multiple cancers including non-small cell lung cancer (NSCLC) and colorectal cancer. Although KRAS was considered undruggable until recently, several KRAS inhi...

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Autori principali: Pierre-Antoine Laurent, Marina Milic, Clément Quevrin, Lydia Meziani, Winchygn Liu, Daphné Morel, Nicolas Signolle, Céline Clémenson, Antonin Levy, Michele Mondini, Eric Deutsch
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2023-10-01
Serie:Journal of Translational Medicine
Soggetti:
MRTX1257
Radiotherapy
KRAS inhibitors
Tumor
Radio-sensitizing
KRAS G12C
Accesso online:https://doi.org/10.1186/s12967-023-04619-0
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