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Immune checkpoint blockade induces distinct alterations in the microenvironments of primary and metastatic brain tumors

In comparison with responses in recurrent glioblastoma (rGBM), the intracranial response of brain metastases (BrM) to immune checkpoint blockade (ICB) is less well studied. Here, we present an integrated single-cell RNA-Seq (scRNA-Seq) study of 19 ICB-naive and 9 ICB-treated BrM samples from our own...

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Principais autores: Lu Sun, Jenny C. Kienzler, Jeremy G. Reynoso, Alexander Lee, Eileen Shiuan, Shanpeng Li, Jiyoon Kim, Lizhong Ding, Amber J. Monteleone, Geoffrey C. Owens, Joanna J. Phillips, Richard G. Everson, David Nathanson, Timothy F. Cloughesy, Gang Li, Linda M. Liau, Willy Hugo, Won Kim, Robert M. Prins
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2023-09-01
Colecção:The Journal of Clinical Investigation
Assuntos:
Immunology
Neuroscience
Acesso em linha:https://doi.org/10.1172/JCI169314
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