Basal parasympathetic deficits in C9orf72 hexanucleotide repeat expansion carriers relate to smaller frontoinsula and thalamus volume and lower empathy

Diminished basal parasympathetic nervous system activity is a feature of frontotemporal dementia that relates to left frontoinsula dysfunction and empathy impairment. Individuals with a pathogenic expansion of the hexanucleotide repeat in chromosome 9 open reading frame 72 (C9orf72), the most common...

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Autori principali:	Ashlin R. K. Roy, Fate Noohi, Nathaniel A. Morris, Peter Ljubenkov, Hilary Heuer, Jamie Fong, Matthew Hall, Argentina Lario Lago, Katherine P. Rankin, Bruce L. Miller, Adam L. Boxer, Howard J. Rosen, William W. Seeley, David C. Perry, Jennifer S. Yokoyama, Suzee E. Lee, Virginia E. Sturm
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2024-01-01
Serie:	NeuroImage: Clinical
Soggetti:	Autonomic nervous system Prosocial behavior Insula Behavioral variant frontotemporal dementia C9orf72
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2213158224000883
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