Basal parasympathetic deficits in C9orf72 hexanucleotide repeat expansion carriers relate to smaller frontoinsula and thalamus volume and lower empathy

Diminished basal parasympathetic nervous system activity is a feature of frontotemporal dementia that relates to left frontoinsula dysfunction and empathy impairment. Individuals with a pathogenic expansion of the hexanucleotide repeat in chromosome 9 open reading frame 72 (C9orf72), the most common...

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Principais autores:	Ashlin R. K. Roy, Fate Noohi, Nathaniel A. Morris, Peter Ljubenkov, Hilary Heuer, Jamie Fong, Matthew Hall, Argentina Lario Lago, Katherine P. Rankin, Bruce L. Miller, Adam L. Boxer, Howard J. Rosen, William W. Seeley, David C. Perry, Jennifer S. Yokoyama, Suzee E. Lee, Virginia E. Sturm
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2024-01-01
叢編:	NeuroImage: Clinical
主題:	Autonomic nervous system Prosocial behavior Insula Behavioral variant frontotemporal dementia C9orf72
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2213158224000883
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