Mutagenetic analysis of the biosynthetic pathway of tetramate bripiodionen bearing 3-(2H-pyran-2-ylidene)pyrrolidine-2,4-dione skeleton

Abstract Background Natural tetramates are a family of hybrid polyketides bearing tetramic acid (pyrrolidine-2,4-dione) moiety exhibiting a broad range of bioactivities. Biosynthesis of tetramates in microorganisms is normally directed by hybrid polyketide synthase (PKS) and nonribosomal peptide syn...

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Autori principali:	Haixia Zang, Yijia Cheng, Mengjia Li, Lin Zhou, Li-Li Hong, Hai Deng, Hou-Wen Lin, Yongjun Zhou
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-03-01
Serie:	Microbial Cell Factories
Soggetti:	Tetramic acid Dieckmann cyclase Nonribosomal peptide synthetase Aminoacyl transthiolation
Accesso online:	https://doi.org/10.1186/s12934-024-02364-7
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