Identification of driver genes based on gene mutational effects and network centrality

Abstract Background As one of the deadliest diseases in the world, cancer is driven by a few somatic mutations that disrupt the normal growth of cells, and leads to abnormal proliferation and tumor development. The vast majority of somatic mutations did not affect the occurrence and development of c...

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Bibliografski detalji

Glavni autori:	Yun-Yun Tang, Pi-Jing Wei, Jian-ping Zhao, Junfeng Xia, Rui-Fen Cao, Chun-Hou Zheng
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2021-09-01
Serija:	BMC Bioinformatics
Teme:	Cancer Driver genes Mutation data Local centrality Transcriptional network
Online pristup:	https://doi.org/10.1186/s12859-021-04377-0
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