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Dynamic functional assessment of T cells reveals an early suppression correlating with adverse outcome in polytraumatized patients

IntroductionMost trauma patients require intensive care treatment and are susceptible to developing persistent inflammation and immunosuppression, potentially leading to multi organ dysfunction syndrome (MODS) and dependence on long term care facilities. T cells undergo changes in numbers and functi...

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Principais autores: Tobias Jooss, Katharina Maier, Lena-Marie Reichardt, Bianca Hindelang, Lönna Süberkrüb, Kim Lena Hamberger, Jasmin Maria Bülow, Konrad Schuetze, Florian Gebhard, Marco Mannes, Rebecca Halbgebauer, Lisa Wohlgemuth, Markus Huber-Lang, Borna Relja, Christian B. Bergmann
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-03-01
Serier:Frontiers in Immunology
Fag:
trauma
immunomonitoring
T cells
interferon gamma
CD8 T cells
prediction
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538516/full
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