Drug Interaction PBPK Modeling: Review of the Literature Exposes the Need for Increased Verification of Model Inputs and Outputs as Part of Credibility Assessment

ABSTRACT In vitro data are routinely used to support both static and physiologically based pharmacokinetic (PBPK) model‐based drug–drug interaction (DDI) predictions. Such efforts are possible after years of rapid progress, enabled by the greater availability of in vitro reagents, kinetic models, an...

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Hauptverfasser:	David Rodrigues, Christopher R. Gibson, Nina Isoherranen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2025-07-01
Schriftenreihe:	Clinical and Translational Science
Schlagworte:	biopsy drug interaction induction inhibition modeling PBPK
Online-Zugang:	https://doi.org/10.1111/cts.70299
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