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Temperature-Controlled Diastereoselective Doebner/Ugi Tandem Reaction

Novel peptidomimetics containing a pyrrolone fragment were synthesized by a tandem combination of Doebner and Ugi type multicomponent reactions with controlled diastereoselectivity. This approach represents a convenient synthesis in the temperature range from 25 to 45 °C. In most cases, the new meth...

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Furkejuvvon:
Váldodahkkit: Yana Sakhno, Oleksandr Radchenko, Vyacheslav Saraev, Yuliia Shliapkina, Mariia Kaidash, Mariia Shyshkina, Svitlana Shishkina, Vladimir Musatov, Sergey Desenko, Valentyn Chebanov
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Georg Thieme Verlag KG 2023-05-01
Ráidu:SynOpen
Fáttát:
multicomponent reactions
doebner reaction
ugi reaction
peptidomimetics
pyrrolones
diastereoselectivity
Liŋkkat:http://www.thieme-connect.de/DOI/DOI?10.1055/a-2091-7934
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