Gal3‐CaN‐Smurf1 Complex Sequestrates FLCN‐FNIPs to Facilitate TFEB Activation in Response to Endomembrane Damage

Abstract Smurf1 mediates lysosomal biogenesis upon endomembrane damage by interacting with lysosomal injury sensor Gal3 and phosphatase CaN to form Gal3‐CaN‐Smurf1 complex, which is critical for TFEB dephosphorylation. However, whether Smurf1 plays a role in the inhibition of mTOR‐mediated TFEB phos...

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Библиографические подробности

Главные авторы:	Qin Xia, Ziwan Liu, Gaoqing Feng, Wanting Xu, HuaHua Wang, Haihang Su, Jiaqian Li, Dan Liu, Jun Qu, Tonghui Yu, Lei Dong
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Wiley 2025-10-01
Серии:	Advanced Science
Предметы:	endomembrane damage FLCN‐FNIPs Gal3‐CaN‐Smurf1 complex lysosomal stress TFEB ubiquitylation
Online-ссылка:	https://doi.org/10.1002/advs.202413241
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