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Gal3‐CaN‐Smurf1 Complex Sequestrates FLCN‐FNIPs to Facilitate TFEB Activation in Response to Endomembrane Damage

Abstract Smurf1 mediates lysosomal biogenesis upon endomembrane damage by interacting with lysosomal injury sensor Gal3 and phosphatase CaN to form Gal3‐CaN‐Smurf1 complex, which is critical for TFEB dephosphorylation. However, whether Smurf1 plays a role in the inhibition of mTOR‐mediated TFEB phos...

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Principais autores: Qin Xia, Ziwan Liu, Gaoqing Feng, Wanting Xu, HuaHua Wang, Haihang Su, Jiaqian Li, Dan Liu, Jun Qu, Tonghui Yu, Lei Dong
פורמט: Artigo
שפה:Inglês
יצא לאור: Wiley 2025-10-01
סדרה:Advanced Science
נושאים:
endomembrane damage
FLCN‐FNIPs
Gal3‐CaN‐Smurf1 complex
lysosomal stress
TFEB
ubiquitylation
גישה מקוונת:https://doi.org/10.1002/advs.202413241
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