Upregulated DNMT3a coupling with inhibiting p62-dependent autophagy contributes to NNK tumorigenicity in human bronchial epithelial cells

NNK, formally known as 4-(methyl nitrosamine)-1-(3-pyridyl)-1-butanoe, is a potent chemical carcinogen prevalent in cigarette smoke and is a key contributor to the development of human lung adenocarcinomas. On the other hand, autophagy plays a complex role in cancer development, acting as a ''double...

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Bibliografische Detailangaben

Hauptverfasser:	Xuelei Liu, Jingjing Wang, Ziyi Yang, Qipeng Xie, Xinqi Diao, Xiaoyan Yao, Shirui Huang, Ruifan Chen, Yunping Zhao, Tengda Li, Minghua Jiang, Zhefeng Lou, Chuanshu Huang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2024-11-01
Schriftenreihe:	Ecotoxicology and Environmental Safety
Schlagworte:	NNK p62 HuR DNMT3a mTOR/S6 lung carcinogenesis
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S0147651324012338
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