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Nicotine Inhibits the Cytotoxicity and Genotoxicity of NNK Mediated by CYP2A13 in BEAS-2B Cells

Both tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and nicotine can be metabolized by cytochrome P450 2A13 (CYP2A13). Previous studies have shown that nicotine has a potential inhibitory effect on the toxicity of NNK. However, due to the lack of CYP2A13 activity in...

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Huvudupphov: Yulin Sun, Hongjuan Wang, Huan Chen, Sen Zhang, Jun Li, Jingni Zhang, Jianlu Tian, Youyu Zhang, Hongwei Hou, Qingyuan Hu
Materialtyp: Artigo
Språk:Inglês
Utgiven: MDPI AG 2022-07-01
Serie:Molecules
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Länkar:https://www.mdpi.com/1420-3049/27/15/4851
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