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Topological regulation of a transmembrane protein by luminal-to-cytosolic retrotranslocation of glycosylated sequence

Summary: Transmembrane proteins must adopt proper topology to perform their functions. We previously demonstrated that ceramide regulates TM4SF20 (transmembrane 4 L6 family 20) by altering the topology of the transmembrane protein, but the underlying mechanism remains obscure. Here we report that TM...

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Hlavní autoři: Jingcheng Wang, Sungwon Han, Jin Ye
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2023-04-01
Edice:Cell Reports
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On-line přístup:http://www.sciencedirect.com/science/article/pii/S2211124723003224
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