Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome

Summary: Polycomb repressive complex (PRC) 2 represses transcription through histone H3K27 trimethylation (H3K27me3). We previously reported that the hematopoietic-cell-specific deletion of Ezh2, encoding a PRC2 enzyme, induced myelodysplastic syndrome (MDS) in mice, whereas the concurrent Ezh1 dele...

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Detalhes bibliográficos

Principais autores:	Kazumasa Aoyama, Motohiko Oshima, Shuhei Koide, Emi Suzuki, Makiko Mochizuki-Kashio, Yuko Kato, Shiro Tara, Daisuke Shinoda, Nobuhiro Hiura, Yaeko Nakajima-Takagi, Goro Sashida, Atsushi Iwama
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2018-11-01
coleção:	iScience
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589004218301676
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