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Pretreatment of trans-ferulic acid improved neurotoxicity in a thioacetamide-induced hepatic encephalopathy rat model; participation of the MAPK/NF-κb signaling pathway

AimTrans-ferulic acid (TFA), a naturally occurring phenolic compound, has attracted significant attention due to its strong hepatoprotective and neuroprotective properties. Despite extensive research on its overall biological activities, the specific mechanisms by which TFA influences hepatic enceph...

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Principais autores: Adil Furkan Kilic, Bahadir Suleyman, Renad Mammadov, Seval Bulut, Ali Sefa Mendil, Halis Suleyman
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-05-01
coleção:Frontiers in Pharmacology
Assuntos:
hepatic encephalopathy
MAPK/NF-κB
rats
thioacetamide
trans-ferulic acid
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2026.1750709/full
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