PGC-1α regulates critical period onset/closure, mediating cortical plasticity

Peroxisome proliferator-activated receptor PPARγ coactivator-α (PGC-1α) is concentrated in inhibitory interneurons and plays a vital role in neuropsychiatric diseases. We previously reported some characteristic features of schizophrenia (SZ) in GABAergic neuron-specific Pgc-1alpha knockout (KO) mice...

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Auteurs principaux:	Wei-Jun Zhang, Hou-Zhen Shi, Mei-Na Guo, Long-Fei Xu, Hong-Ru Zhai, Zi-Zhong Liu, Yong-Qiang Zhu, Wei-Ning Zhang, Jia Wang
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2023-09-01
Collection:	Frontiers in Molecular Neuroscience
Sujets:	cortex matrix metalloproteinase 9 (MMP9) parvalbumin interneurons (PVIs) perineuronal nets (PNNs) PGC-1alpha
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fnmol.2023.1149906/full
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