Comprehensive enhancer-target gene assignments improve gene set level interpretation of genome-wide regulatory data

Abstract Background Revealing the gene targets of distal regulatory elements is challenging yet critical for interpreting regulome data. Experiment-derived enhancer-gene links are restricted to a small set of enhancers and/or cell types, while the accuracy of genome-wide approaches remains elusive d...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Tingting Qin, Christopher Lee, Shiting Li, Raymond G. Cavalcante, Peter Orchard, Heming Yao, Hanrui Zhang, Shuze Wang, Snehal Patil, Alan P. Boyle, Maureen A. Sartor
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2022-04-01
Edice:	Genome Biology
Témata:	Enhancer Target gene Gene Ontology Gene set enrichment test Genomic regions ChIP-seq
On-line přístup:	https://doi.org/10.1186/s13059-022-02668-0
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!