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NK cells propagate T cell immunity following in situ tumor vaccination

Summary: We report an in situ vaccination, adaptable to nearly any type of cancer, that combines radiotherapy targeting one tumor and intratumoral injection of this site with tumor-specific antibody and interleukin-2 (IL-2; 3xTx). In a phase I clinical trial, administration of 3xTx (with an immunocy...

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Príomhchruthaitheoirí: Won Jong Jin, Justin C. Jagodinsky, Jessica M. Vera, Paul A. Clark, Cindy L. Zuleger, Amy K. Erbe, Irene M. Ong, Trang Le, Kaitlin Tetreault, Tracy Berg, Alexander L. Rakhmilevich, KyungMann Kim, Michael A. Newton, Mark R. Albertini, Paul M. Sondel, Zachary S. Morris
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Elsevier 2023-12-01
Sraith:Cell Reports
Ábhair:
Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S2211124723015681
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