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Concise Synthesis of Catechin Metabolites 5-(3′,4′-Dihydroxyphenyl)-γ-valerolactones (DHPV) in Optically Pure Form and Their Stereochemical Effects on Skin Wrinkle-Reducing Activities

A concise and scalable synthetic route for optically pure (4<i>S</i>) and (4<i>R</i>)-5-(3′,4′-dihydroxyphenyl)-γ-valerolactones (DHPVs), catechin metabolites, has been developed via the efficient construction of a γ-valerolactone moiety from hexenol. Noticeably, the different skin wrinkle-reducing...

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Principais autores: Joonseong Hur, A-Ram Kim, Hyun Su Kim, Changjin Lim, Taewoo Kim, Tae-Aug Kim, Jaehoon Sim, Young-Ger Suh
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-04-01
Serier:Molecules
Fag:
catechin metabolite
γ-valerolactone
concise synthesis
skin wrinkle-reducing activity
Online adgang:https://www.mdpi.com/1420-3049/25/8/1970
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