Asymmetric attrition and secondary chromosome destabilization after double-strand breaks in human embryonic development

Abstract DNA repair in human embryos is poorly understood, and double-strand breaks (DSBs) can cause chromosome loss. We show that chromosomal alterations relative to an induced DSB are asymmetric: acentric arms show complementary gains and losses, while centric arms are biased toward losses. Centro...

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Autores principales:	Jenna Turocy, Stepan Jerabek, Woonyung Hur, Jimin Kim, Shuangyi Xu, Qiaojin Zhao, Jia Xu, Alex Robles, Xiangyi Liu, Nathan Treff, Diego Marin, Anna-Katerina Hadjantonakis, Dieter Egli
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2026-06-01
Colección:	Nature Communications
Acceso en línea:	https://doi.org/10.1038/s41467-026-73891-7
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